| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Mouse/Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SYVN1 (460-510 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
Syvn1 |
| Gene ID: |
74126 |
| Uniprot ID: |
SYVN1_MOUSE |
| Immunogen Region: |
460-510 aa |
| Specificity: |
Specific for SYVN1. |
| Immunogen: |
A synthetic peptide from aa region 460-510 of mouse SYVN1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation. Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis. Required for embryogenesis. Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1. During the early stage of B cell development, required for degradation of the pre-B cell receptor (pre-BCR) complex, hence supporting further differentiation into mature B cells. |
| Protein Name | E3 Ubiquitin-Protein Ligase SynoviolinRing-Type E3 Ubiquitin Transferase SynoviolinSynovial Apoptosis Inhibitor 1 |
| Database Links | Reactome: R-MMU-5358346 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Synoviolin antibodyAnti-Ring-Type E3 Ubiquitin Transferase Synoviolin antibodyAnti-Synovial Apoptosis Inhibitor 1 antibodyAnti-Syvn1 antibodyAnti-Hrd1 antibodyAnti-Kiaa1810 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
