Anti-SYTL2 antibody (STJA0009693)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SYTL2
General Information
| Short Description | Rabbit polyclonal anti-Synaptotagmin-like protein 2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYTL2 |
| Gene ID | 54843 |
| Uniprot ID | SYTL2_HUMAN |
| Immunogen | Synthesized peptide derived from human SYTL2 |
| Specificity | This antibody detects endogenous levels of SYTL2 at Human, Mouse |
Additional Info
| Post Translational Modifications | Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A. |
| Function | Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. |
| Protein Name | Synaptotagmin-Like Protein 2Breast Cancer-Associated Antigen Sga-72mExophilin-4 |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Isoform 1: CytoplasmCell MembraneRecruited On Vesicular Structures In Cytotoxic T-Lymphocytes (Ctl) By Rab27aIsoform 4: Cell MembraneIn The Pancreatic Alpha Cells Distributed In Both Peripheral And Anterior RegionsLocalizes On The Glucagon Granules In The Cell Periphery |
| Alternative Antibody Names | Anti-Synaptotagmin-Like Protein 2 antibodyAnti-Breast Cancer-Associated Antigen Sga-72m antibodyAnti-Exophilin-4 antibodyAnti-SYTL2 antibodyAnti-KIAA1597 antibodyAnti-SGA72M antibodyAnti-SLP2 antibodyAnti-SLP2A antibody |
Information sourced from Uniprot.org