Anti-Syt7 antibody (Internal) (STJ72358)

SKU:
STJ72358-100

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Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Syt7 (Internal) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SYT7
Gene ID: 9066
Uniprot ID: SYT7_HUMAN
Immunogen Region: Internal
Accession Number: NP_004191.2
Immunogen Sequence: DIPTEKLRET
Post Translational Modifications Palmitoylated at its vesicular N-terminus.palmitoylation is required for localization to lysosome and phagocytosis in macrophages.
Function Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes.both actions contribute to triggering exocytosis. SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins. Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair. Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages. Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts. In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis. Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes. Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters. Probably mediates synaptic facilitation by directly increasing the probability of release. May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin. Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells. Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells. Also regulates the secretion of some non-synaptic secretory granules of specialized cells.
Protein Name Synaptotagmin-7
Ipca-7
Prostate Cancer-Associated Protein 7
Synaptotagmin Vii
Sytvii
Database Links Reactome: R-HSA-6794361
Cellular Localisation Cell Membrane
Single-Pass Membrane Protein
Presynaptic Cell Membrane
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Lysosome Membrane
Phagosome Membrane
Peroxisome Membrane
Secretory Vesicle Membrane
Localization To Lysosomes Is Dependent On N-Terminal Palmitoylation And Interaction With Cd63
Alternative Antibody Names Anti-Synaptotagmin-7 antibody
Anti-Ipca-7 antibody
Anti-Prostate Cancer-Associated Protein 7 antibody
Anti-Synaptotagmin Vii antibody
Anti-Sytvii antibody
Anti-SYT7 antibody
Anti-PCANAP7 antibody

Information sourced from Uniprot.org

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