Anti-SYT4 antibody (38-190) (STJ110048)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SYT4 (38-190) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYT4 |
| Gene ID | 6860 |
| Uniprot ID | SYT4_HUMAN |
| Immunogen Region | 38-190 |
| Immunogen Sequence | CQRKSSKSNKTPPYKFVHVL KGVDIYPENLNSKKKFGADD KNEVKNKPAVPKNSLHLDLE KRDLNGNFPKTNLKPGSPSD LENATPKLFLEGEKESVSPE SLKSSTSLTSEEKQEKLGTL FFSLEYNFERKAFVVNIKEA RGLPAMDEQSMTS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 38-190 of human SYT4 (NP_065834.1). |
Additional Info
| Tissue Specificity | Expressed in melanocytes. Expressed in brain. Within brain, expression is highest in hippocampus, with substantial levels also detected in amygdala and thalamus. |
| Post Translational Modifications | Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility. |
| Function | Synaptotagmin family member which does not bind Ca(2+). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses. Plays a role in dendrite formation by melanocytes. |
| Protein Name | Synaptotagmin-4Synaptotagmin IvSytiv |
| Database Links | |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleNeuronal Dense Core Vesicle MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Synaptotagmin-4 antibodyAnti-Synaptotagmin Iv antibodyAnti-Sytiv antibodyAnti-SYT4 antibodyAnti-KIAA1342 antibody |
Information sourced from Uniprot.org