Anti-Syntaxin4 antibody (Internal Region) (STJ13100346)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from internal region of mouse Syntaxin4 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-Syntaxin4 (Internal Region) for use in IHC and WB in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:2000 is recommended for WB and 1:1000 for IHC-P. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | STX4 |
| Gene ID | 6810 |
| Uniprot ID | STX4_HUMAN |
| Immunogen | A synthetic peptide from internal region of mouse Syntaxin4 conjugated to blue carrier protein was used as the antigen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for Syntaxin4. |
Additional Info
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing. |
| Protein Name | Syntaxin-4Renal Carcinoma Antigen Ny-Ren-31 |
| Database Links | Reactome: R-HSA-114516Reactome: R-HSA-1236974Reactome: R-HSA-1445148Reactome: R-HSA-199992Reactome: R-HSA-449836 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iv Membrane ProteinCell ProjectionNeuron ProjectionStereociliumLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Syntaxin-4 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-31 antibodyAnti-STX4 antibodyAnti-STX4A antibody |
Information sourced from Uniprot.org