Anti-Syntaxin 4 antibody [R07-1G2] (STJA0034905)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Syntaxin 4
General Information
| Short Description | Rabbit monoclonal anti-Syntaxin 4 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-1G2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | STX4 |
| Gene ID | 6810 |
| Uniprot ID | STX4_HUMAN |
| Immunogen | A synthetic peptide of human Syntaxin 4 |
Additional Info
| Tissue Specificity | Expressed in neutrophils and neutrophil-differentiated HL-60 cells. Expression in neutrophils increases with differentiation. |
| Function | Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones. Required for normal hearing. |
| Protein Name | Syntaxin-4Renal Carcinoma Antigen Ny-Ren-31 |
| Database Links | Reactome: R-HSA-114516Reactome: R-HSA-1236974Reactome: R-HSA-1445148Reactome: R-HSA-199992Reactome: R-HSA-449836 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iv Membrane ProteinCell ProjectionNeuron ProjectionStereociliumLocalizes To Neurite Tips In Neuronal Cells |
| Alternative Antibody Names | Anti-Syntaxin-4 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-31 antibodyAnti-STX4 antibodyAnti-STX4A antibody |
Information sourced from Uniprot.org