• Western blot analysis of various lysates using SYNJ1 Rabbit polyclonal antibody (STJ119653) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-SYNJ1 antibody (100-200) (STJ119653)

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STJ119653

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SYNJ1 (100-200) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SYNJ1
Gene ID: 8867
Uniprot ID: SYNJ1_HUMAN
Immunogen Region: 100-200
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SYNJ1 (NP_003886.3).
Immunogen Sequence: GLLGVLRLNLGDTMLHYLVL VTGCMSVGKIQESEVFRVTS TEFISLRIDSSDEDRISEVR KVLNSGNFYFAWSASGISLD LSLNAHRSMQEQTTDNRFFW N
Tissue Specificity Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.
Function Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2.
Protein Name Synaptojanin-1
Synaptic Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 1
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-1855183
Reactome: R-HSA-1855204
Reactome: R-HSA-8856828
Cellular Localisation Cytoplasm
Perinuclear Region
Alternative Antibody Names Anti-Synaptojanin-1 antibody
Anti-Synaptic Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 1 antibody
Anti-SYNJ1 antibody
Anti-KIAA0910 antibody

Information sourced from Uniprot.org

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