| Host: |
Mouse |
| Applications: |
WB/IHC |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Synaptojanin 1 (C-Term) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
5H1 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was protein g purified culture from supernatant. |
| Dilution Range: |
WB 1:1000IHC 1:100ICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Synj1 |
| Gene ID: |
85238 |
| Uniprot ID: |
SYNJ1_RAT |
| Immunogen Region: |
C-Term |
| Immunogen: |
Recombinant protein from the C-terminal region of rat synaptojanin 1. |
| Tissue Specificity | Isoform 1 is found in neonatal brain, and in a wide variety of adult non-neuronal tissues. Isoform 2 is expressed predominantly in the neurons, but is also found in all other tissues at much lower levels. Isoform 1 and isoform 2 are detected in the lung and heart. Isoform 1 is expressed at higher levels than isoform 2 in the testis and liver and both isoforms are not detected in the skeletal muscle. Isoform 3 with the 16-amino-acid insert is only found in the brain while isoform 3 without the 16-amino-acid insert is found in the lung. |
| Function | Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate. Has a role in clathrin-mediated endocytosis. Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2. |
| Protein Name | Synaptojanin-1Synaptic Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 1 |
| Database Links | Reactome: R-RNO-1660499Reactome: -RNO-1855183Reactome: -RNO-1855204Reactome: -RNO-8856828 |
| Cellular Localisation | CytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Synaptojanin-1 antibodyAnti-Synaptic Inositol 1 -4 -5-Trisphosphate 5-Phosphatase 1 antibodyAnti-Synj1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
