Anti-SYNE4 antibody (STJA0008773)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Nesprin 4
General Information
| Short Description | Rabbit polyclonal anti-Nesprin-4 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SYNE4 |
| Gene ID | 163183 |
| Uniprot ID | SYNE4_HUMAN |
| Immunogen | Synthesized peptide derived from human Nesprin 4 |
| Specificity | This antibody detects endogenous levels of Nesprin 4 at Human, Mouse, Rat |
Additional Info
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus. |
| Protein Name | Nesprin-4Kash Domain-Containing Protein 4Kash4Nuclear Envelope Spectrin Repeat Protein 4 |
| Database Links | |
| Cellular Localisation | Nucleus Outer MembraneSingle-Pass Type Iv Membrane ProteinLocalization At The Nucleus Outer Membrane Requires The Presence Of Sun1 |
| Alternative Antibody Names | Anti-Nesprin-4 antibodyAnti-Kash Domain-Containing Protein 4 antibodyAnti-Kash4 antibodyAnti-Nuclear Envelope Spectrin Repeat Protein 4 antibodyAnti-SYNE4 antibodyAnti-C19orf46 antibody |
Information sourced from Uniprot.org