Anti-Synaptotagmin2 antibody (STJ13100321)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from rat Synaptotagmin2 conjugated to blue carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-Synaptotagmin2 for use in IHC and WB in Human, Rat, Mouse and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:1000 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Syt2 |
| Gene ID | 20980 |
| Uniprot ID | SYT2_MOUSE |
| Immunogen | A synthetic peptide from rat Synaptotagmin2 conjugated to blue carrier protein was used as the antigen. |
| Specificity | Specific for SYTII. |
Additional Info
| Function | Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties. May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. Plays a role in dendrite formation by melanocytes. (Microbial infection) Receptor for C.botulinum neurotoxin type B (BoNT/B, botB).interaction is improved in the presence of gangliosides. The toxin binds via the vesicular domain (residues 47-60). (Microbial infection) Receptor for C.botulinum neurotoxin type G (BoNT/G, botG).gangliosides are not required for (or only very slightly improve) binding to a membrane-anchored receptor fragment. The toxin binds via the vesicular domain (residues 47-55). |
| Protein Name | Synaptotagmin-2Inositol Polyphosphate-Binding ProteinIp4-Binding ProteinIp4bpSynaptotagmin IiSytii |
| Database Links | Reactome: R-MMU-8856825Reactome: -MMU-8856828 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Membrane ProteinChromaffin Granule MembraneCytoplasm |
| Alternative Antibody Names | Anti-Synaptotagmin-2 antibodyAnti-Inositol Polyphosphate-Binding Protein antibodyAnti-Ip4-Binding Protein antibodyAnti-Ip4bp antibodyAnti-Synaptotagmin Ii antibodyAnti-Sytii antibodyAnti-Syt2 antibody |
Information sourced from Uniprot.org