| Tissue Specificity | Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue. Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages. |
| Post Translational Modifications | Tyrosine-phosphorylated. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion. |
| Protein Name | Switch-Associated Protein 70Swap-70 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell MembraneNucleusCell ProjectionLamellipodiumCytoskeletonIn Resting B-Cells It Is Localized Mainly In The Cytoplasm And Upon Cell Activation It Is Recruited To The Plasma Membrane And Then Translocates To The NucleusIn ActivatedClass-Switching B-Cells It Is Associated With Membrane Igg But Not IgmLocalized To Loose Actin Filament Arrays Located Behind Actively Extending Lamellipodia |
| Alternative Antibody Names | Anti-Switch-Associated Protein 70 antibodyAnti-Swap-70 antibodyAnti-SWAP70 antibodyAnti-KIAA0640 antibodyAnti-HSPC321 antibody |
Information sourced from Uniprot.org
