| Host: |
Mouse |
| Applications: |
WB/IP |
| Reactivity: |
Human/Mouse/Rat/Monkey |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Switch-associated protein 70 is suitable for use in Western Blot and Immunoprecipitation research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
2E9-E8-E9 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2b |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SWAP70 |
| Gene ID: |
23075 |
| Uniprot ID: |
SWP70_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SWAP70 and does not cross-react with related proteins. |
| Immunogen: |
Purified recombinant human SWAP70 protein fragments expressed in E.coli. |
| Post Translational Modifications | Tyrosine-phosphorylated. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion. |
| Protein Name | Switch-Associated Protein 70Swap-70 |
| Database Links | Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCell MembraneNucleusCell ProjectionLamellipodiumCytoskeletonIn Resting B-Cells It Is Localized Mainly In The Cytoplasm And Upon Cell Activation It Is Recruited To The Plasma Membrane And Then Translocates To The NucleusIn ActivatedClass-Switching B-Cells It Is Associated With Membrane Igg But Not IgmLocalized To Loose Actin Filament Arrays Located Behind Actively Extending Lamellipodia |
| Alternative Antibody Names | Anti-Switch-Associated Protein 70 antibodyAnti-Swap-70 antibodyAnti-SWAP70 antibodyAnti-KIAA0640 antibodyAnti-HSPC321 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
