![Anti-SV-40 antibody [MRQ-4] (STJ16100426)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/149143/346763/STJ16100426_1__11835.1681998861.jpg?c=1 "Anti-SV-40 antibody [MRQ-4] (STJ16100426)")
![Anti-SV-40 antibody [MRQ-4] (STJ16100426)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/149143/346763/STJ16100426_1__11835.1681998861.jpg?c=1 "Anti-SV-40 antibody [MRQ-4] (STJ16100426)")
Anti-SV-40 antibody [MRQ-4] (STJ16100426)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal anti-SV-40 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | MRQ-4 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Dilution Range | IHC 1:50 – 1:200 |
| Formulation | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
Additional Info
| Background | SV40, Simian Virus 40 is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the transcriptional properties of tumor-suppressing p53 in humans through the SV40 large T-antigen and SV40 small T-antigen. It is generally assumed that large T-antigen is the major protein involved in neoplastic processes and the large T-antigen predominantly exerts its effect through deregulation of tumor suppressor p53, which is responsible for initiating regulated cell death (“apoptosis”) , or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor. |
Information sourced from Uniprot.org