Anti-SUV39H2 antibody (141-350) (STJ28418)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SUV39H2 (141-350) antibody for use in WB, ELISA and ChIP in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/ChIP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.ChIP:5 Mu g antibody for 10 Mu g-15 Mu g of Chromatin |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SUV39H2 |
| Gene ID | 79723 |
| Uniprot ID | SUV92_HUMAN |
| Immunogen Region | 141-350 |
| Immunogen Sequence | CCPAEAGVLLAYNKNQQIKI PPGTPIYECNSRCQCGPDCP NRIVQKGTQYSLCIFRTSNG RGWGVKTLVKIKRMSFVMEY VGEVITSEEAERRGQFYDNK GITYLFDLDYESDEFTVDAA RYGNVSHFVNHSCDPNLQVF NVFIDNLDTRLPRIALFSTR TINAGEELTFDYQMKGSGDI SSDSIDHSPAKKRVRTVCKC GAVTCRGYLN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 141-350 of human SUV39H2 (NP_001180354.1). |
Additional Info
| Post Translational Modifications | Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation. |
| Function | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
| Protein Name | Histone-Lysine N-Methyltransferase Suv39h2Histone H3-K9 Methyltransferase 2H3-K9-Hmtase 2Lysine N-Methyltransferase 1bSuppressor Of Variegation 3-9 Homolog 2Su(Var3-9 Homolog 2 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With Centromeric Constitutive Heterochromatin |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Suv39h2 antibodyAnti-Histone H3-K9 Methyltransferase 2 antibodyAnti-H3-K9-Hmtase 2 antibodyAnti-Lysine N-Methyltransferase 1b antibodyAnti-Suppressor Of Variegation 3-9 Homolog 2 antibodyAnti-Su(Var3-9 Homolog 2 antibodyAnti-SUV39H2 antibodyAnti-KMT1B antibody |
Information sourced from Uniprot.org