Anti-SUV39H2 antibody (111-160 aa) (STJ93852)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SUV39H2 at the amino acid range 111-160
General Information
| Short Description | Rabbit polyclonal anti-Histone-lysine N-methyltransferase SUV39H23-9 homolog 2 (111-160 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SUV39H2 |
| Gene ID | 79723 |
| Uniprot ID | SUV92_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SUV39H2 at the amino acid range 111-160 |
| Immunogen Region | 111-160 aa |
| Specificity | KMT1B Polyclonal Antibody detects endogenous levels of KMT1B protein. |
Additional Info
| Function | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation. |
| Protein Name | Histone-Lysine N-Methyltransferase Suv39h2Histone H3-K9 Methyltransferase 2H3-K9-Hmtase 2Lysine N-Methyltransferase 1bSuppressor Of Variegation 3-9 Homolog 2Su(Var3-9 Homolog 2 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosomeCentromereAssociates With Centromeric Constitutive Heterochromatin |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Suv39h2 antibodyAnti-Histone H3-K9 Methyltransferase 2 antibodyAnti-H3-K9-Hmtase 2 antibodyAnti-Lysine N-Methyltransferase 1b antibodyAnti-Suppressor Of Variegation 3-9 Homolog 2 antibodyAnti-Su(Var3-9 Homolog 2 antibodyAnti-SUV39H2 antibodyAnti-KMT1B antibody |
Information sourced from Uniprot.org