Anti-SUN1 antibody (STJA0008735)

SKU:
STJA0008735

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SUN domain-containing protein 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SUN1
Gene ID: 23353
Uniprot ID: SUN1_HUMAN
Specificity: This antibody detects endogenous levels of SUN1 at Human, Mouse
Immunogen: Synthesized peptide derived from human SUN1
Function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links.
Protein Name Sun Domain-Containing Protein 1
Protein Unc-84 Homolog A
Sad1/Unc-84 Protein-Like 1
Database Links Reactome: R-HSA-1221632
Cellular Localisation Nucleus Inner Membrane
Single-Pass Type Ii Membrane Protein
At Oocyte Mi Stage Localized Around The Spindle
At Mii Stage Localized To The Spindle Poles
Alternative Antibody Names Anti-Sun Domain-Containing Protein 1 antibody
Anti-Protein Unc-84 Homolog A antibody
Anti-Sad1/Unc-84 Protein-Like 1 antibody
Anti-SUN1 antibody
Anti-KIAA0810 antibody
Anti-UNC84A antibody

Information sourced from Uniprot.org

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