Anti-SUN1 antibody [R09-8V4] (STJA0036969)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human SUN1
General Information
| Short Description | Rabbit monoclonal anti-SUN1 for use in WB, IHC-P, ICC, IF and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-8V4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SUN1 |
| Gene ID | 23353 |
| Uniprot ID | SUN1_HUMAN |
| Immunogen | A synthesized peptide derived from human SUN1 |
Additional Info
| Post Translational Modifications | The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces. |
| Function | As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenesis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links. |
| Protein Name | Sun Domain-Containing Protein 1Protein Unc-84 Homolog ASad1/Unc-84 Protein-Like 1 |
| Database Links | Reactome: R-HSA-1221632 |
| Cellular Localisation | Nucleus Inner MembraneSingle-Pass Type Ii Membrane ProteinAt Oocyte Mi Stage Localized Around The SpindleAt Mii Stage Localized To The Spindle Poles |
| Alternative Antibody Names | Anti-Sun Domain-Containing Protein 1 antibodyAnti-Protein Unc-84 Homolog A antibodyAnti-Sad1/Unc-84 Protein-Like 1 antibodyAnti-SUN1 antibodyAnti-KIAA0810 antibodyAnti-UNC84A antibody |
Information sourced from Uniprot.org