Anti-SULT2A1 antibody (1-145) (STJ27442)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SULT2A1 (1-145) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SULT2A1 |
| Gene ID | 6822 |
| Uniprot ID | ST2A1_HUMAN |
| Immunogen Region | 1-145 |
| Immunogen Sequence | MSDDFLWFEGIAFPTMGFRS ETLRKVRDEFVIRDEDVIIL TYPKSGTNWLAEILCLMHSK GDAKWIQSVPIWERSPWVES EIGYTALSETESPRLFSSHL PIQLFPKSFFSSKAKVIYLM RNPRDVLVSGYFFWKNMKFI KKPKS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human SULT2A1 (NP_003158.2). |
Additional Info
| Tissue Specificity | Liver, adrenal and at lower level in the kidney. Is present in human fetus in higher level in the adrenal than the liver and the kidney. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands. Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism. In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols. |
| Protein Name | Sulfotransferase 2a1St2a1Bile Salt SulfotransferaseDehydroepiandrosterone SulfotransferaseDhea-StDhea-St8Hydroxysteroid SulfotransferaseHstSt2Sult2a3 |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-1989781Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sulfotransferase 2a1 antibodyAnti-St2a1 antibodyAnti-Bile Salt Sulfotransferase antibodyAnti-Dehydroepiandrosterone Sulfotransferase antibodyAnti-Dhea-St antibodyAnti-Dhea-St8 antibodyAnti-Hydroxysteroid Sulfotransferase antibodyAnti-Hst antibodyAnti-St2 antibodyAnti-Sult2a3 antibodyAnti-SULT2A1 antibodyAnti-HST antibodyAnti-STD antibody |
Information sourced from Uniprot.org