Anti-SULT1A1 antibody (STJA0007050)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SULT1A1
General Information
| Short Description | Rabbit polyclonal anti-Sulfotransferase 1A1 for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SULT1A1 |
| Gene ID | 6817 |
| Uniprot ID | ST1A1_HUMAN |
| Immunogen | Synthesized peptide derived from human SULT1A1 |
| Specificity | This antibody detects endogenous levels of SULT1A1 at Human, Rat |
Additional Info
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones. Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. Catalyzes the sulfate conjugation of dopamine. Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4. |
| Protein Name | Sulfotransferase 1a1St1a1Aryl Sulfotransferase 1Hast1/Hast2Phenol Sulfotransferase 1Phenol-Sulfating Phenol Sulfotransferase 1P-Pst 1St1a3Thermostable Phenol SulfotransferaseTs-Pst |
| Database Links | Reactome: R-HSA-156584Reactome: R-HSA-9753281 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sulfotransferase 1a1 antibodyAnti-St1a1 antibodyAnti-Aryl Sulfotransferase 1 antibodyAnti-Hast1/Hast2 antibodyAnti-Phenol Sulfotransferase 1 antibodyAnti-Phenol-Sulfating Phenol Sulfotransferase 1 antibodyAnti-P-Pst 1 antibodyAnti-St1a3 antibodyAnti-Thermostable Phenol Sulfotransferase antibodyAnti-Ts-Pst antibodyAnti-SULT1A1 antibodyAnti-STP antibodyAnti-STP1 antibodyAnti-OK antibodyAnti-SW-cl.88 antibody |
Information sourced from Uniprot.org