| Post Translational Modifications | Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains. |
| Function | Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. |
| Protein Name | Sin3 Histone Deacetylase Corepressor Complex Component Sds345 Kda Sin3-Associated PolypeptideSuppressor Of Defective Silencing 3 Protein Homolog |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-5689880Reactome: R-HSA-9679191 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Sin3 Histone Deacetylase Corepressor Complex Component Sds3 antibodyAnti-45 Kda Sin3-Associated Polypeptide antibodyAnti-Suppressor Of Defective Silencing 3 Protein Homolog antibodyAnti-SUDS3 antibodyAnti-SAP45 antibodyAnti-SDS3 antibody |
Information sourced from Uniprot.org
