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Anti-STX1A antibody (31-80 aa) (STJ96805)

Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded human-lung, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
Western blot analysis of K562 cells using Syntaxin 1 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-STX1A antibody (31-80 aa) (STJ96805)

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STJ96805

€57.50 - €282.50

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General Information
Product Properties
Target Information
Additional Info
Warranty Information

Host:	Rabbit
Applications:	WB/IHC/IF/ELISA
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-Syntaxin-1A (31-80 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC-P 1:100-1:300 ELISA 1:20000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	STX1A
Gene ID:	6804
Uniprot ID:	STX1A_HUMAN
Immunogen Region:	31-80 aa
Specificity:	Syntaxin 1 Polyclonal Antibody detects endogenous levels of Syntaxin 1 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the Internal region of human STX1A at the amino acid range 31-80

Post Translational Modifications	Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis.
Function	Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis. Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm. Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1).
Protein Name	Syntaxin-1a Neuron-Specific Antigen Hpc-1
Database Links	Reactome: R-HSA-181429 Reactome: R-HSA-181430 Reactome: R-HSA-210500 Reactome: R-HSA-212676 Reactome: R-HSA-264642 Reactome: R-HSA-264876 Reactome: R-HSA-422356 Reactome: R-HSA-449836 Reactome: R-HSA-5250971 Reactome: R-HSA-5682910 Reactome: R-HSA-6794361 Reactome: R-HSA-888590 Reactome: R-HSA-9609523 Reactome: R-HSA-9662360
Cellular Localisation	Cytoplasmic Vesicle Secretory Vesicle Synaptic Vesicle Membrane Single-Pass Type Iv Membrane Protein Synapse Synaptosome Cell Membrane Colocalizes With Kcnb1 At The Cell Membrane Isoform 2: Secreted
Alternative Antibody Names	Anti-Syntaxin-1a antibody Anti-Neuron-Specific Antigen Hpc-1 antibody Anti-STX1A antibody Anti-STX1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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