Anti-STRA13 antibody (1-63) (STJ111934)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal STRA13 (1-63) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | CENPX |
| Gene ID | 201254 |
| Uniprot ID | CENPX_HUMAN |
| Immunogen Region | 1-63 |
| Immunogen Sequence | MEGAGAGSGFRKELVSRLLH LHFKDDKTKEAAVRGVRQAQ AEDALRVDVDQLEKVLPQLL LDF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-63 of human STRA13 (NP_659435.2). |
Additional Info
| Function | DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. |
| Protein Name | Centromere Protein XCenp-XFancm-Associated Histone Fold Protein 2Fancm-Interacting Histone Fold Protein 2Fanconi Anemia-Associated Polypeptide Of 10 KdaRetinoic Acid-Inducible Gene D9 Protein HomologStimulated By Retinoic Acid Gene 13 Protein Homolog |
| Database Links | Reactome: R-HSA-606279Reactome: R-HSA-6783310Reactome: R-HSA-9833482 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreAssembly Of Cenps And Cenpx And Its Partner Subunits Cenpt And Cenpw At Centromeres Occurs Through A Dynamic Exchange MechanismAlthough Exchange Is Continuous In The Cell CycleDe Novo Assembly Starts Principally During Mid-Late S Phase And Is Complete By G2Cenpx Being Less Stably Bound At The Kinetochore Than Cenps |
| Alternative Antibody Names | Anti-Centromere Protein X antibodyAnti-Cenp-X antibodyAnti-Fancm-Associated Histone Fold Protein 2 antibodyAnti-Fancm-Interacting Histone Fold Protein 2 antibodyAnti-Fanconi Anemia-Associated Polypeptide Of 10 Kda antibodyAnti-Retinoic Acid-Inducible Gene D9 Protein Homolog antibodyAnti-Stimulated By Retinoic Acid Gene 13 Protein Homolog antibodyAnti-CENPX antibodyAnti-FAAP10 antibodyAnti-MHF2 antibodyAnti-STRA13 antibody |
Information sourced from Uniprot.org