| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STOML2 (29-356) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STOML2 |
| Gene ID: |
30968 |
| Uniprot ID: |
STML2_HUMAN |
| Immunogen Region: |
29-356 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 29-356 of human STOML2 (NP_038470.1). |
| Immunogen Sequence: |
SSGLPRNTVVLFVPQQEAWV VERMGRFHRILEPGLNILIP VLDRIRYVQSLKEIVINVPE QSAVTLDNVTLQIDGVLYLR IMDPYKASYGVEDPEYAVTQ LAQTTMRSELGKLSLDKVFR ERESLNASIVDAINQAADCW GIRCLRYEIKDIHVPPRVKE SMQMQVEAERRKRATVLESE GTRESAINVAEGKKQAQILA SEAEKAEQINQAAGEASAVL AKAKAKAEAIRILAAALTQ |
| Tissue Specificity | Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level). |
| Post Translational Modifications | Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A. |
| Function | Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. |
| Protein Name | Stomatin-Like Protein 2 - MitochondrialSlp-2Epb72-Like Protein 2Paraprotein Target 7Paratarg-7 |
| Database Links | Reactome: R-HSA-8949664 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinMitochondrionMitochondrion Inner MembraneLipid-AnchorMitochondrion Intermembrane SpaceMembrane RaftCytoplasmCytoskeletonBehaves As An Integral Membrane Protein Of The Mitochondrion Despite The Absence Of A Detectable Transmembrane DomainAlso Associates With The Actin Cytoskeleton And Membrane Rafts In Activated T-CellsA Minor Pool Is Associated With The Plasma Membrane And Is Enriched At The Immunological Synapse In Activated T-Cells |
| Alternative Antibody Names | Anti-Stomatin-Like Protein 2 - Mitochondrial antibodyAnti-Slp-2 antibodyAnti-Epb72-Like Protein 2 antibodyAnti-Paraprotein Target 7 antibodyAnti-Paratarg-7 antibodyAnti-STOML2 antibodyAnti-SLP2 antibodyAnti-HSPC108 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
