Anti-STMN2 antibody (C-Term) (STJ13102140)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of mouse STMN2 conjugated to an immunogenic carrier protein was used as the antigen. the peptide is homologous in rat and human.
General Information
| Short Description | Rabbit polyclonal anti-STMN2 (C-Term) for use in IHC and WB in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Stmn2 |
| Gene ID | 20257 |
| Uniprot ID | STMN2_MOUSE |
| Immunogen | A synthetic peptide from c-terminal region of mouse STMN2 conjugated to an immunogenic carrier protein was used as the antigen. the peptide is homologous in rat and human. |
| Immunogen Region | C-Term |
| Specificity | Specific for Stathmin 2. |
Additional Info
| Post Translational Modifications | Sumoylated. Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15. |
| Function | Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. |
| Protein Name | Stathmin-2Superior Cervical Ganglion-10 ProteinProtein Scg10 |
| Database Links | Reactome: R-MMU-9696273 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell ProjectionGrowth ConeAxonMembranePeripheral Membrane ProteinCytoplasmic SideEndosomeGolgi ApparatusLamellipodiumColocalized With Cib1 In Neurites Of Developing Hippocampal Primary NeuronsColocalized With Cib1 In The Cell BodyNeuritisGrowth Cones Of Neurons And In Neurites Of Developing Hippocampal Primary NeuronsColocalized With Cib1 To The Leading Edge Of LamellipodiaAssociated With Punctate Structures In The Perinuclear CytoplasmAxonsAnd Growth Cones Of Developing NeuronsExists In Both Soluble And Membrane-Bound FormsIn The Developing BrainMostly Cytosolic |
| Alternative Antibody Names | Anti-Stathmin-2 antibodyAnti-Superior Cervical Ganglion-10 Protein antibodyAnti-Protein Scg10 antibodyAnti-Stmn2 antibodyAnti-Scg10 antibodyAnti-Scgn10 antibodyAnti-Stmb2 antibody |
Information sourced from Uniprot.org