| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/EIA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-STMN1/Stathmin 1 (C-Term) is suitable for use in ELISA, Western Blot, EIA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlIHC-3.75µg/mlELISA-antibody detection limit dilution 1:1000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
STMN1 |
| Gene ID: |
3925 |
| Uniprot ID: |
STMN1_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_005554.1; NP_981944.1; NP_981946.1 |
| Specificity: |
This antibody is expected to cross-react with isoform 1 a (NP_005554.1; NP_981944.1; NP_981946.1) only. The three reported isoforms (NP_005554.1, NP_981944.1 and NP_981946.1) represent identical protein. |
| Immunogen Sequence: |
KNKESKDPADETEAD |
| Post Translational Modifications | Many different phosphorylated forms are observed depending on specific combinations among the sites which can be phosphorylated. MAPK is responsible for the phosphorylation of stathmin in response to NGF. Phosphorylation at Ser-16 seems to be required for neuron polarization. Phosphorylation at Ser-63 reduces tubulin binding 10-fold and suppresses the MT polymerization inhibition activity. |
| Function | Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear. |
| Protein Name | StathminLeukemia-Associated Phosphoprotein P18MetablastinOncoprotein 18Op18Phosphoprotein P19Pp19ProsolinProtein Pr22Pp17 |
| Database Links | Reactome: R-HSA-1251985 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Stathmin antibodyAnti-Leukemia-Associated Phosphoprotein P18 antibodyAnti-Metablastin antibodyAnti-Oncoprotein 18 antibodyAnti-Op18 antibodyAnti-Phosphoprotein P19 antibodyAnti-Pp19 antibodyAnti-Prosolin antibodyAnti-Protein Pr22 antibodyAnti-Pp17 antibodyAnti-STMN1 antibodyAnti-C1orf215 antibodyAnti-LAP18 antibodyAnti-OP18 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
