Anti-STK36 antibody (C-Term) (STJ71907)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-STK36 (C-Term) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments in Human Testis lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). We would appreciate any feedback from people in the |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | STK36 |
| Gene ID | 27148 |
| Uniprot ID | STK36_HUMAN |
| Accession Number | NP_056505.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | QSLPHSSPRPASAK |
Additional Info
| Function | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. |
| Protein Name | Serine/Threonine-Protein Kinase 36Fused Homolog |
| Cellular Localisation | CytoplasmNucleusCytoskeletonCilium AxonemeLow Levels Also Present In The Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 36 antibodyAnti-Fused Homolog antibodyAnti-STK36 antibodyAnti-KIAA1278 antibody |
Information sourced from Uniprot.org