Anti-STK36 antibody (387-436 aa) (STJ95827)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human STK36 at the amino acid range 387-436
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase 36 (387-436 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STK36 |
| Gene ID | 27148 |
| Uniprot ID | STK36_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human STK36 at the amino acid range 387-436 |
| Immunogen Region | 387-436 aa |
| Specificity | STK36 Polyclonal Antibody detects endogenous levels of STK36 protein. |
Additional Info
| Function | Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia. |
| Protein Name | Serine/Threonine-Protein Kinase 36Fused Homolog |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCytoskeletonCilium AxonemeLow Levels Also Present In The Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 36 antibodyAnti-Fused Homolog antibodyAnti-STK36 antibodyAnti-KIAA1278 antibody |
Information sourced from Uniprot.org