| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-STK24 (312-431) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
STK24 |
| Gene ID: |
8428 |
| Uniprot ID: |
STK24_HUMAN |
| Immunogen Region: |
312-431 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 312-431 of human STK24 (NP_001027467.2). |
| Immunogen Sequence: |
TDGQASGGSDSGDWIFTIRE KDPKNLENGALQPSDLDRNK MKDIPKRPFSQCLSTIISPL FAELKEKSQACGGNLGSIEE LRGAIYLAEEACPGISDTMV AQLVQRLQRYSLSGGGTSSH |
| Tissue Specificity | Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. |
| Post Translational Modifications | Proteolytically processed by caspases during apoptosis. Proteolytic cleavage results in kinase activation, nuclear translocation of the truncated form (MST3/N) and the induction of apoptosis. Isoform B is activated by phosphorylation by PKA. Oxidative stress induces phosphorylation. Activated by autophosphorylation at Thr-190 and phosphorylation at this site is essential for its function. Manganese, magnesium and cobalt-dependent autophosphorylation is mainly on threonine residues while zinc-dependent autophosphorylation is on both serine and threonine residues. |
| Function | Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. |
| Protein Name | Serine/Threonine-Protein Kinase 24Mammalian Ste20-Like Protein Kinase 3Mst-3Ste20-Like Kinase Mst3 Cleaved Into - Serine/Threonine-Protein Kinase 24 36 Kda SubunitMammalian Ste20-Like Protein Kinase 3 N-TerminalMst3/N - Serine/Threonine-Protein Kinase 24 12 Kda SubunitMammalian Ste20-Like Protein Kinase 3 C-TerminalMst3/C |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-75153 |
| Cellular Localisation | CytoplasmNucleusMembraneThe Truncated Form (Mst3/N) Translocates To The NucleusColocalizes With Stk38l In The Membrane |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 24 antibodyAnti-Mammalian Ste20-Like Protein Kinase 3 antibodyAnti-Mst-3 antibodyAnti-Ste20-Like Kinase Mst3 Cleaved Into - Serine/Threonine-Protein Kinase 24 36 Kda Subunit antibodyAnti-Mammalian Ste20-Like Protein Kinase 3 N-Terminal antibodyAnti-Mst3/N - Serine/Threonine-Protein Kinase 24 12 Kda Subunit antibodyAnti-Mammalian Ste20-Like Protein Kinase 3 C-Terminal antibodyAnti-Mst3/C antibodyAnti-STK24 antibodyAnti-MST3 antibodyAnti-STK3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
