Anti-STK10 antibody (491-540 aa) (STJ93943)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human STK10 at the amino acid range 491-540
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase 10 (491-540 aa) for use in WB, ELISA and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STK10 |
| Gene ID | 6793 |
| Uniprot ID | STK10_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human STK10 at the amino acid range 491-540 |
| Immunogen Region | 491-540 aa |
| Specificity | LOK Polyclonal Antibody detects endogenous levels of LOK protein. |
Additional Info
| Post Translational Modifications | Autophosphorylates following homodimerization, leading to activation of the protein. |
| Function | Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro.however such data require additional evidences in vivo. |
| Protein Name | Serine/Threonine-Protein Kinase 10Lymphocyte-Oriented Kinase |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | Cell MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase 10 antibodyAnti-Lymphocyte-Oriented Kinase antibodyAnti-STK10 antibodyAnti-LOK antibody |
Information sourced from Uniprot.org