Anti-STAU2 antibody (300-400) (STJ25728)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal STAU2 (300-400) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAU2 |
| Gene ID | 27067 |
| Uniprot ID | STAU2_HUMAN |
| Immunogen Region | 300-400 |
| Immunogen Sequence | PEYGQGMNPISRLAQIQQAK KEKEPDYVLLSERGMPRRRE FVMQVKVGNEVATGTGPNKK IAKKNAAEAMLLQLGYKAST NLQDQLEKTGENKGWSGPKP G |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human STAU2 (NP_001157852.1). |
Additional Info
| Function | RNA-binding protein required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite. As protein synthesis occurs within the dendrite, the localization of specific mRNAs to dendrites may be a prerequisite for neurite outgrowth and plasticity at sites distant from the cell body. |
| Protein Name | Double-Stranded Rna-Binding Protein Staufen Homolog 2 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusEndoplasmic ReticulumShuttles Between The NucleolusNucleus And The CytoplasmNuclear Export Of Isoform 1 Is Independent Of Xpo1/Crm1 And Requires The Exportin Xpo5Nuclear Export Of Isoform 2 And Isoform 3 Can Occur By Both Xpo1/Crm1-Dependent And Xpo1/Crm1-Independent PathwaysFound In Large Cytoplasmic Ribonucleoprotein (Rnp) Granules Which Are Present In The Actin Rich Regions Of Myelinating Processes And Associated With MicrotubulesPolysomes And The Endoplasmic ReticulumAlso Recruited To Stress Granules (Sgs) Upon Inhibition Of Translation Or Oxidative StressThese Structures Are Thought To Harbor Housekeeping Mrnas When Translation Is Aborted |
| Alternative Antibody Names | Anti-Double-Stranded Rna-Binding Protein Staufen Homolog 2 antibodyAnti-STAU2 antibody |
Information sourced from Uniprot.org