| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | STAT6 |
| Gene ID: | 6778 |
| Uniprot ID: | STAT6_HUMAN |
| Immunogen Region: | 501-600 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 501-600 of human STAT6 (NP_003144.3). |
| Immunogen Sequence: | QFNKEILLGRGFTFWQWFDG VLDLTKRCLRSYWSDRLIIG FISKQYVTSLLLNEPDGTFL LRFSDSEIGGITIAHVIRGQ DGSPQIENIQPFSAKDLSIR SLGDRIRDLAQLKNLYPKKP KDEAFRSHYKPEQMGKDGRG YVPATIKMTVERDQPLPTPE LQMPTMVPSYDLGMAPDSSM SMQLGPDMVPQVYPPHSHSI PPYQGLSPEESVNVLSAFQE PHLQMPPSLGQMSLPFDQP |
| Post Translational Modifications | Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling. Mono-ADP-ribosylated by PARP14. |
| Function | Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. |
| Protein Name | Signal Transducer And Activator Of Transcription 6Il-4 Stat |
| Database Links | Reactome: R-HSA-186763Reactome: R-HSA-3249367Reactome: R-HSA-6785807 |
| Cellular Localisation | CytoplasmNucleusTranslocated Into The Nucleus In Response To Phosphorylation |
| Alternative Antibody Names | Anti-Signal Transducer And Activator Of Transcription 6 antibodyAnti-Il-4 Stat antibodyAnti-STAT6 antibody |
Information sourced from Uniprot.org