Anti-STAM2 antibody (Internal) (STJ70906)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-STAM2 (Internal) is suitable for use in ELISA, Western Blot and Flow Cytometry research applications. |
| Applications | Pep-ELISA/WB/FC |
| Host | Goat |
| Reactivity | Human/Mouse/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Approx 70kDa band observed in Human Spleen lysates and in preliminary testing of HeLa cell lysate (calculated MW of 58.2kDa according to NP_005834.3). This molecular weight is routinely |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | STAM2 |
| Gene ID | 10254 |
| Uniprot ID | STAM2_HUMAN |
| Accession Number | NP_005834.3 |
| Immunogen Region | Internal |
| Immunogen Sequence | QSIDPTDSKPDSQD |
| Specificity | No cross-reaction expected with STAM1. |
Additional Info
| Post Translational Modifications | Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. |
| Protein Name | Signal Transducing Adapter Molecule 2Stam-2Hrs-Binding Protein |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-5689880Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-9013420Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Signal Transducing Adapter Molecule 2 antibodyAnti-Stam-2 antibodyAnti-Hrs-Binding Protein antibodyAnti-STAM2 antibodyAnti-HBP antibody |
Information sourced from Uniprot.org