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Anti-STAM2 antibody (376-525) (STJ29138)

Immunofluorescence analysis of U-2 OS cells using STAM2 antibody (STJ29138) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of L929 cells using STAM2 antibody (STJ29138) at dilution of 1:100. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of C6 cells using STAM2 antibody (STJ29138) at dilution of 1:100. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using STAM2 antibody (STJ29138) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.

Anti-STAM2 antibody (376-525) (STJ29138)

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STJ29138

£169.50 - £449.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-STAM2 (376-525) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:100
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	STAM2
Gene ID:	10254
Uniprot ID:	STAM2_HUMAN
Immunogen Region:	376-525
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human STAM2 (NP_005834.4).
Immunogen Sequence:	KLHPPAHYPPASSGVPMQTY PVQSHGGNYMGQSIHQVTVA QSYSLGPDQIGPLRSLPPNV NSSVTAQPAQTSYLSTGQDT VSNPTYMNQNSNLQSATGTT AYTQQMGMSVDMSSYQNTTS NLPQLAGFPVTVPAHPVAQQ HTNYHQQPLL

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Function	Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
Protein Name	Signal Transducing Adapter Molecule 2 Stam-2 Hrs-Binding Protein
Database Links	Reactome: R-HSA-182971 Reactome: R-HSA-5689880 Reactome: R-HSA-6807004 Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8875360 Reactome: R-HSA-9013420 Reactome: R-HSA-917729
Cellular Localisation	Cytoplasm Early Endosome Membrane Peripheral Membrane Protein Cytoplasmic Side
Alternative Antibody Names	Anti-Signal Transducing Adapter Molecule 2 antibody Anti-Stam-2 antibody Anti-Hrs-Binding Protein antibody Anti-STAM2 antibody Anti-HBP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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