Anti-STAM1, 2 antibody (STJ13100332)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from human STAM 1, 2 (STAM-1, STAM-2) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse, zebra fish and xenopus.
General Information
| Short Description | Rabbit polyclonal anti-STAM1, 2 for use in IHC and WB in Human, Rat, Mouse and Marmoset samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse/Marmoset |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 5000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | STAM |
| Gene ID | 8027 |
| Uniprot ID | STAM1_HUMAN |
| Immunogen | A synthetic peptide from human STAM 1, 2 (STAM-1, STAM-2) conjugated to blue carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse, zebra fish and xenopus. |
| Specificity | Specific for STAM1 & 2. |
Additional Info
| Post Translational Modifications | Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB. Ubiquitinated by ITCH. |
| Function | Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. (Microbial infection) Plays an important role in Dengue virus entry. |
| Protein Name | Signal Transducing Adapter Molecule 1Stam-1 |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-5689901Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8875360Reactome: R-HSA-9013420Reactome: R-HSA-917729 |
| Cellular Localisation | CytoplasmEarly Endosome MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Signal Transducing Adapter Molecule 1 antibodyAnti-Stam-1 antibodyAnti-STAM antibodyAnti-STAM1 antibody |
Information sourced from Uniprot.org