Anti-ST8SIA3 antibody (STJA0009165)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ST8SIA3
General Information
| Short Description | Rabbit polyclonal anti-Sia-alpha-2, 3-Gal-beta-1, 4-GlcNAc-R:alpha 2, 8-sialyltransferase for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ST8SIA3 |
| Gene ID | 51046 |
| Uniprot ID | SIA8C_HUMAN |
| Immunogen | Synthesized peptide derived from human ST8SIA3 |
| Specificity | This antibody detects endogenous levels of ST8SIA3 at Human, Mouse |
Additional Info
| Post Translational Modifications | Autopolysialylated. |
| Function | Catalyzes the transfer of sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an acceptor, such as N-linked oligosaccharides of glycoproteins and glycolipids through alpha-2,8-linkages. Forms oligosialic and polysialic acid on various sialylated N-acetyllactosamine oligosaccharides of glycoproteins, including FETUB N-glycans, a2-HS-glycoprotein (AHSG) and alpha 2,3-sialylated glycosphingolipids, such as alpha 2,3-sialylparagloboside and ganglioside GM3 and to a lesser extent NCAM1 N-glycans. However, it is much more specific to N-linked oligosaccharides of glycoproteins than glycosphingolipids. 2,3-sialylparagloboside serves as the best acceptor substrate among the glycolipids. alpha-Neu5Ac-(2->8)-alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6S-D-GlcNAc and monosialyl and disialyl N-acetyllactosamines are the best acceptor substrates among glycoproteins. May plays critical role in the striatum by mediating the formation of disialylated and trisialylated terminal glycotopes on N- and O-glycans of specific striatal proteins, regulating their distribution in lipid rafts, affecting their interaction with other binding partners, and subsequently modulating striatal functions. |
| Protein Name | Alpha-N-Acetylneuraminate Alpha-2 -8-Sialyltransferase St8sia3Alpha-2 -8-Sialyltransferase 8cAlpha-2 -8-Sialyltransferase IiiGanglioside Gd3 Synthase St8sia3St8 Alpha-N-Acetyl-Neuraminide Alpha-2 -8-Sialyltransferase 3Sia-A2 -3-Gal-B1 -4-Glc-Nac-R -A2 -8-SialyltransferaseHst8sia IiiSialyltransferase 8cSiat8-CSialyltransferase St8sia IiiSt8siaiii |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylneuraminate Alpha-2 -8-Sialyltransferase St8sia3 antibodyAnti-Alpha-2 -8-Sialyltransferase 8c antibodyAnti-Alpha-2 -8-Sialyltransferase Iii antibodyAnti-Ganglioside Gd3 Synthase St8sia3 antibodyAnti-St8 Alpha-N-Acetyl-Neuraminide Alpha-2 -8-Sialyltransferase 3 antibodyAnti-Sia-A2 -3-Gal-B1 -4-Glc-Nac-R -A2 -8-Sialyltransferase antibodyAnti-Hst8sia Iii antibodyAnti-Sialyltransferase 8c antibodyAnti-Siat8-C antibodyAnti-Sialyltransferase St8sia Iii antibodyAnti-St8siaiii antibodyAnti-ST8SIA3 antibodyAnti-SIAT8C antibody |
Information sourced from Uniprot.org