Anti-ST8SIA2 antibody (STJ193022)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Alpha-2, 8-sialyltransferase 8B for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ST8SIA2 |
| Gene ID | 8128 |
| Uniprot ID | SIA8B_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SIA8B Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autopolysialylated. Autopolysialylation is not a prerequisite for the polysialylation acitity, but enhances the polysialylation acitity. |
| Function | Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan acceptor through alpha-2,8-linkages (Probable). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides (alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid), including NCAM1, NCAM1 N-glycans, FETUB N-glycans, and to a lesser extent sialylparagloboside (SPG) and AHSG, which does not require the initial addition of an alpha 2,8-sialic acid (Probable). However, does not exhibit sialic acid-polymerase activity. Catalyzes polysialic acid synthesis in the hippocampal on NCAM1 and supports neurite outgrowth. ST8SIA2-mediated polysialylation influences on oligodendrocyte differentiation and may promote the integrity of myelin and axons. |
| Protein Name | Alpha-2 -8-Sialyltransferase 8bSialyltransferase 8bSiat8-BSialyltransferase St8sia IiSt8siaiiSialyltransferase XStx |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-419037Reactome: R-HSA-975577 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane ProteinSecretedCell MembraneAlso Trafficks To The Cell Surface |
| Alternative Antibody Names | Anti-Alpha-2 -8-Sialyltransferase 8b antibodyAnti-Sialyltransferase 8b antibodyAnti-Siat8-B antibodyAnti-Sialyltransferase St8sia Ii antibodyAnti-St8siaii antibodyAnti-Sialyltransferase X antibodyAnti-Stx antibodyAnti-ST8SIA2 antibodyAnti-SIAT8B antibodyAnti-STX antibody |
Information sourced from Uniprot.org