Anti-ST6GALNAC5 antibody (28-336) (STJ119815)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ST6GALNAC5 (28-336) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ST6GALNAC5 |
| Gene ID | 81849 |
| Uniprot ID | SIA7E_HUMAN |
| Immunogen Region | 28-336 |
| Immunogen Sequence | SLGGQKERPPQQQQQQQQQQ QQASATGSSQPAAESSTQQR PGVPAGPRPLDGYLGVADHK PLKMHCRDCALVTSSGHLLH SRQGSQIDQTECVIRMNDAP TRGYGRDVGNRTSLRVIAHS SIQRILRNRHDLLNVSQGTV FIFWGPSSYMRRDGKGQVYN NLHLLSQVLPRLKAFMITRH KMLQFDELFKQETGKDRKIS NTWLSTGWFTMTIALELCDR INVYGMVPPDFCRDPNHPS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 28-336 of human ST6GALNAC5 (NP_112227.1). |
Additional Info
| Function | Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b. GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis. Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen. |
| Protein Name | Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 5Gd1 Alpha SynthaseGalnac Alpha-2 -6-Sialyltransferase VSt6galnac VSt6galnacvSialyltransferase 7eSiat7-E |
| Database Links | Reactome: R-HSA-4085001Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Alpha-N-Acetylgalactosaminide Alpha-2 -6-Sialyltransferase 5 antibodyAnti-Gd1 Alpha Synthase antibodyAnti-Galnac Alpha-2 -6-Sialyltransferase V antibodyAnti-St6galnac V antibodyAnti-St6galnacv antibodyAnti-Sialyltransferase 7e antibodyAnti-Siat7-E antibodyAnti-ST6GALNAC5 antibodyAnti-SIAT7E antibody |
Information sourced from Uniprot.org