Anti-ST3GAL2 antibody (STJA0009700)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human ST3GAL2
General Information
| Short Description | Rabbit polyclonal anti-CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ST3GAL2 |
| Gene ID | 6483 |
| Uniprot ID | SIA4B_HUMAN |
| Immunogen | Synthesized peptide derived from human ST3GAL2 |
| Specificity | This antibody detects endogenous levels of ST3GAL2 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | The soluble form derives from the membrane form by proteolytic processing. N-glycosylated.necessary for proper exit from endoplasmic reticulum and trafficking to the Golgi apparatus. |
| Function | A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids. Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid.Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage. Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively. Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration. Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury. Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell-associated antigen SSEA3, forming SSEA4. Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta-(1->3)-GalNAc-O-Ser. |
| Protein Name | Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 2Alpha 2 -3-St 2Beta-Galactoside Alpha-2 -3-Sialyltransferase 2Gal-Nac6sGal-Beta-1 -3-Galnac-Alpha-2 -3-SialyltransferaseMonosialoganglioside SialyltransferaseSt3gal IiSt3galiiSt3gala.2Sialyltransferase 4bSiat4-B |
| Database Links | Reactome: R-HSA-2022854Reactome: R-HSA-4085001Reactome: R-HSA-9683673Reactome: R-HSA-9694548Reactome: R-HSA-9694719Reactome: R-HSA-977068Reactome: R-HSA-9840309 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form Distributed Along The Golgi CisternaeMainly In Proximal CompartmentsSecreted Into The Body Fluid |
| Alternative Antibody Names | Anti-Cmp-N-Acetylneuraminate-Beta-Galactosamide-Alpha-2 -3-Sialyltransferase 2 antibodyAnti-Alpha 2 -3-St 2 antibodyAnti-Beta-Galactoside Alpha-2 -3-Sialyltransferase 2 antibodyAnti-Gal-Nac6s antibodyAnti-Gal-Beta-1 -3-Galnac-Alpha-2 -3-Sialyltransferase antibodyAnti-Monosialoganglioside Sialyltransferase antibodyAnti-St3gal Ii antibodyAnti-St3galii antibodyAnti-St3gala.2 antibodyAnti-Sialyltransferase 4b antibodyAnti-Siat4-B antibodyAnti-ST3GAL2 antibodyAnti-SIAT4B antibody |
Information sourced from Uniprot.org