| Host: |
Goat |
| Applications: |
Pep-ELISA/WB/IHC |
| Reactivity: |
Human/Mouse/Rat/Dog/Pig/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SSP29/ANP32B (C-Term) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
IHC-3-5µg/mlELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ANP32B |
| Gene ID: |
10541 |
| Uniprot ID: |
AN32B_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_006392.1 |
| Specificity: |
This antibody does NOT recognize theTNF family member also known as APRIL-Gene ID number 8741. However this antibody may cross-react with ANP32A (GeneID 8125). |
| Immunogen Sequence: |
KRKRETDDEGEDD |
| Post Translational Modifications | Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group. Directly cleaved by caspase-3/CASP3. |
| Function | Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription. Regulates the proliferation of neuronal stem cells, differentiation of leukemic cells and progression from G1 to S phase of the cell cycle. As negative regulator of caspase-3-dependent apoptosis, may act as an antagonist of ANP32A in regulating tissue homeostasis. Exhibits histone chaperone properties, able to recruit histones to certain promoters, thus regulating the transcription of specific genes. Also plays an essential role in the nucleocytoplasmic transport of specific mRNAs via the uncommon nuclear mRNA export receptor XPO1/CRM1. Participates in the regulation of adequate adaptive immune responses by acting on mRNA expression and cell proliferation. (Microbial infection) Plays an essential role in influenza A and B viral genome replication. Also plays a role in foamy virus mRNA export from the nucleus to the cytoplasm. |
| Protein Name | Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member BAcidic Protein Rich In LeucinesPutative Hla-Dr-Associated Protein I-2Phapi2Silver-Stainable Protein Ssp29 |
| Cellular Localisation | Isoform 1: NucleusCytoplasmAccumulates In The Nuclei At The S PhaseIsoform 2: CytoplasmLacks A Nuclear Localization Signal |
| Alternative Antibody Names | Anti-Acidic Leucine-Rich Nuclear Phosphoprotein 32 Family Member B antibodyAnti-Acidic Protein Rich In Leucines antibodyAnti-Putative Hla-Dr-Associated Protein I-2 antibodyAnti-Phapi2 antibodyAnti-Silver-Stainable Protein Ssp29 antibodyAnti-ANP32B antibodyAnti-APRIL antibodyAnti-PHAPI2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
