| Short Description : | Rabbit polyclonal SSH2 (53-202) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SSH2 |
| Gene ID: | 85464 |
| Uniprot ID: | SSH2_HUMAN |
| Immunogen Region: | 53-202 |
| Immunogen Sequence: | RGNGSSTPRISHRRNKHAGD LQQHLQAMFILLRPEDNIRL AVRLESTYQNRTRYMVVVST NGRQDTEESIVLGMDFSSND SSTCTMGLVLPLWSDTLIHL DGDGGFSVSTDNRVHIFKPV SVQAMWSALQSLHKACEVAR AHNYYPGSLF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 53-202 of human SSH2 (NP_203747.2). |
| Function | Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. Required for spermatogenesis. Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking. |
| Protein Name | Protein Phosphatase Slingshot Homolog 2Ssh-Like Protein 2Ssh-2lHssh-2l |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionFocal AdhesionCytoplasmic VesicleSecretory VesicleAcrosomeColocalizes With Filamentous Actin In The Cytoplasm And The Cell Periphery |
| Alternative Antibody Names | Anti-Protein Phosphatase Slingshot Homolog 2 antibodyAnti-Ssh-Like Protein 2 antibodyAnti-Ssh-2l antibodyAnti-Hssh-2l antibodyAnti-SSH2 antibodyAnti-KIAA1725 antibodyAnti-SSH2L antibody |
Information sourced from Uniprot.org
