| Post Translational Modifications | Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain. |
| Function | Splicing factor, which binds the consensus motif 5'-CACUAUCACUACC-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing. Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons. Also functions as an adapter involved in mRNA nuclear export. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway).enhances NXF1-NXT1 RNA-binding activity. Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 3Pre-Mrna-Splicing Factor Srp20Splicing Factor - Arginine/Serine-Rich 3 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasmRecruited To Nuclear Speckles Following Interaction With Ythdc1 |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 3 antibodyAnti-Pre-Mrna-Splicing Factor Srp20 antibodyAnti-Splicing Factor - Arginine/Serine-Rich 3 antibodyAnti-SRSF3 antibodyAnti-SFRS3 antibodyAnti-SRP20 antibody |
Information sourced from Uniprot.org
