Anti-SCIN antibody (669-682 aa) [R07-6G2] (STJA0011939)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human SCIN
General Information
| Short Description | Rabbit monoclonal anti-SCIN (669-682 aa) for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-6G2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SCIN |
| Gene ID | 85477 |
| Uniprot ID | SCIN_HUMAN |
| Immunogen | A synthetic peptide of human SCIN |
| Immunogen Region | 669-682 aa |
Additional Info
| Tissue Specificity | Expressed in megakaryocytes. |
| Function | Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways. |
| Protein Name | ScinderinAdseverin |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionPodosome |
| Alternative Antibody Names | Anti-Scinderin antibodyAnti-Adseverin antibodyAnti-SCIN antibodyAnti-KIAA1905 antibody |
Information sourced from Uniprot.org