Anti-SRSF2 antibody [PT1053R] (STJA0039966)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgGk
General Information
| Short Description | Rabbit monoclonal anti-Serine/Arginine-Rich Splicing Factor 2 for use in WB, IHC, IF, IP and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | PT1053R |
| Isotype | IgGk |
| Conjugation | Unconjugated |
| Purification | Protein A |
| Dilution Range | IHC 1:200-1:1000WB 1:2000-1:10000IF 1:200-1:1000ELISA 1:5000-1:20000IP 1:50-1:200 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SRSF2 |
| Gene ID | 6427 |
| Uniprot ID | SRSF2_HUMAN |
| Specificity | Endogenous |
Additional Info
| Function | Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 2Protein Pr264Splicing Component - 35 KdaSplicing Factor Sc35Sc-35Splicing Factor - Arginine/Serine-Rich 2 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleoplasmNucleus SpecklePhosphorylation By Srpk2 Provokes Its Redistribution From The Nuclear Speckle To Nucleoplasm |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 2 antibodyAnti-Protein Pr264 antibodyAnti-Splicing Component - 35 Kda antibodyAnti-Splicing Factor Sc35 antibodyAnti-Sc-35 antibodyAnti-Splicing Factor - Arginine/Serine-Rich 2 antibodyAnti-SRSF2 antibodyAnti-SFRS2 antibody |
Information sourced from Uniprot.org