• Immunohistochemistry of paraffin-embedded rat liver using SRRT antibody (STJ11100951) at dilution of 1:100 (40x lens).
  • Immunohistochemistry analysis of paraffin-embedded mouse testis using SRRT antibody (STJ11100951) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry of paraffin-embedded human gastric cancer using SRRT antibody (STJ11100951) at dilution of 1:100 (40x lens).
  • Immunohistochemistry analysis of paraffin-embedded human gastric cancer using SRRT antibody (STJ11100951) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry of paraffin-embedded mouse testis using SRRT antibody (STJ11100951) at dilution of 1:100 (40x lens).
  • Immunohistochemistry analysis of paraffin-embedded rat liver using SRRT antibody (STJ11100951) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-SRRT antibody (623-872) (STJ11100951)

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STJ11100951

£112.50 - £522.50
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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SRRT (623-872) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SRRT
Gene ID: 51593
Uniprot ID: SRRT_HUMAN
Immunogen Region: 623-872
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 623-872 of human SRRT (NP_001122325.1).
Immunogen Sequence: DYYNTCEYPNEDEMPNRCGI IHVRGPMPPNRISHGEVLEW QKTFEEKLTPLLSVRESLSE EEAQKMGRKDPEQEVEKFVT SNTQELGKDKWLCPLSGKKF KGPEFVRKHIFNKHAEKIEE VKKEVAFFNNFLTDAKRPAL PEIKPAQPPGPAQSLTPGLP YPHQTPQGLMPYGQPRPPIL GYGAGAVRPAVPTGGPPYPH APYGAGRGNYDAFRGQGGYP GKPRNRMVRGDPRAIVEYR
Tissue Specificity Ubiquitously expressed.
Function Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA).however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription.
Protein Name Serrate Rna Effector Molecule Homolog
Arsenite-Resistance Protein 2
Database Links Reactome: R-HSA-6807505
Reactome: R-HSA-72163
Cellular Localisation Nucleus
Nucleoplasm
Cytoplasm
Predominantly Nuclear
Shuttles Between The Nucleus And The Cytoplasm In A Crm1-Dependent Way
Alternative Antibody Names Anti-Serrate Rna Effector Molecule Homolog antibody
Anti-Arsenite-Resistance Protein 2 antibody
Anti-SRRT antibody
Anti-ARS2 antibody
Anti-ASR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance