Anti-SRRM1 antibody (STJ191765)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Serine/arginine repetitive matrix protein 1 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SRRM1 |
| Gene ID | 10250 |
| Uniprot ID | SRRM1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SRRM1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. |
| Protein Name | Serine/Arginine Repetitive Matrix Protein 1Sr-Related Nuclear Matrix Protein Of 160 KdaSrm160Ser/Arg-Related Nuclear Matrix Protein |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72187Reactome: R-HSA-73856Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus MatrixNucleus Speckle |
| Alternative Antibody Names | Anti-Serine/Arginine Repetitive Matrix Protein 1 antibodyAnti-Sr-Related Nuclear Matrix Protein Of 160 Kda antibodyAnti-Srm160 antibodyAnti-Ser/Arg-Related Nuclear Matrix Protein antibodyAnti-SRRM1 antibodyAnti-SRM160 antibody |
Information sourced from Uniprot.org