| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SRPR (1-220) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SRPRA |
| Gene ID: |
6734 |
| Uniprot ID: |
SRPRA_HUMAN |
| Immunogen Region: |
1-220 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SRPR (NP_003130.2). |
| Immunogen Sequence: |
MLDFFTIFSKGGLVLWCFQG VSDSCTGPVNALIRSVLLQE RGGNNSFTHEALTLKYKLDN QFELVFVVGFQKILTLTYVD KLIDDVHRLFRDKYRTEIQQ QSALSLLNGTFDFQNDFLRL LREAEESSKIRAPTTMKKFE DSEKAKKPVRSMIETRGEKP KEKAKNSKKKGAKKEGSDGP LATSKPVPAEKSGLPVGPEN GVELSKEELIRRKREEFIQK |
| Function | Component of the signal recognition particle (SRP) complex receptor (SR). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54. SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER. |
| Protein Name | Signal Recognition Particle Receptor Subunit AlphaSr-AlphaDocking Protein AlphaDp-Alpha |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-381038 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmic SideThought To Be Anchored In The Membrane Through An Interaction With Sr-BetaWhich Contains A Bona Fide Transmembrane Domain |
| Alternative Antibody Names | Anti-Signal Recognition Particle Receptor Subunit Alpha antibodyAnti-Sr-Alpha antibodyAnti-Docking Protein Alpha antibodyAnti-Dp-Alpha antibodyAnti-SRPRA antibodyAnti-SRPR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and Emerin/Emerin/EMD knockout (KO) 293T cells, using [KO Validated] Emerin/EMD Rabbit polyclonal antibody (STJ119989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/98774/382822/STJ119989_1__22320.1713151321.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and Emerin/Emerin/EMD knockout (KO) 293T cells, using [KO Validated] Emerin/EMD Rabbit polyclonal antibody (STJ119989) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")