Anti-SR protein repeat antibody [R39-4Y-8] (STJA0035568)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human SR protein repeat
General Information
| Short Description | Rabbit monoclonal anti-SR protein repeat for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R39-4Y-8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SRSF6 |
| Gene ID | 6431 |
| Uniprot ID | SRSF6_HUMAN |
| Immunogen | A synthesized peptide derived from human SR protein repeat |
Additional Info
| Post Translational Modifications | Extensively phosphorylated on serine residues in the RS domain. Phosphorylated by DYRK1A, probably in the RS domain. Phosphorylation by DYRK1A modulates alternative splice site selection and inhibits the expression of MAPT/Tau exon 10. |
| Function | Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. |
| Protein Name | Serine/Arginine-Rich Splicing Factor 6Pre-Mrna-Splicing Factor Srp55Splicing Factor - Arginine/Serine-Rich 6 |
| Database Links | Reactome: R-HSA-159236Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-72187Reactome: R-HSA-72203Reactome: R-HSA-73856 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Serine/Arginine-Rich Splicing Factor 6 antibodyAnti-Pre-Mrna-Splicing Factor Srp55 antibodyAnti-Splicing Factor - Arginine/Serine-Rich 6 antibodyAnti-SRSF6 antibodyAnti-SFRS6 antibodyAnti-SRP55 antibody |
Information sourced from Uniprot.org