Anti-SQLE antibody (STJA0006752)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SQLE
General Information
| Short Description | Rabbit polyclonal anti-Squalene monooxygenase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SQLE |
| Gene ID | 6713 |
| Uniprot ID | ERG1_HUMAN |
| Immunogen | Synthesized peptide derived from human SQLE |
| Specificity | This antibody detects endogenous levels of SQLE at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation. |
| Function | Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis. |
| Protein Name | Squalene MonooxygenaseSqualene EpoxidaseSe |
| Database Links | Reactome: R-HSA-191273Reactome: R-HSA-2426168 |
| Cellular Localisation | Microsome MembranePeripheral Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Squalene Monooxygenase antibodyAnti-Squalene Epoxidase antibodyAnti-Se antibodyAnti-SQLE antibodyAnti-ERG1 antibody |
Information sourced from Uniprot.org