Anti-SQLE antibody (300-574) (STJ111151)

Name: Anti-SQLE antibody (300-574) (STJ111151)
SKU: STJ111151
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ111151

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Short Description	Rabbit polyclonal SQLE (300-574) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IHC-P:1:50-1:100 IF/ICC:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SQLE
Gene ID	6713
Uniprot ID	ERG1_HUMAN
Immunogen Region	300-574
Immunogen Sequence	VSVSSHFVGFLMKNAPQFKA NHAELILANPSPVLIYQISS SETRVLVDIRGEMPRNLREY MVEKIYPQIPDHLKEPFLEA TDNSHLRSMPASFLPPSSVK K
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 300-400 of human SQLE (NP_003120.2).

Tissue Specificity	Detected in liver (at protein level).
Post Translational Modifications	Ubiquitinated by MARCHF6 in response to high cholesterol levels in intracellular membranes, leading to proteasomal degradation.
Function	Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.
Protein Name	Squalene Monooxygenase Squalene Epoxidase Se
Database Links	Reactome: R-HSA-191273 Reactome: R-HSA-2426168
Cellular Localisation	Microsome Membrane Peripheral Membrane Protein Endoplasmic Reticulum Membrane
Alternative Antibody Names	Anti-Squalene Monooxygenase antibody Anti-Squalene Epoxidase antibody Anti-Se antibody Anti-SQLE antibody Anti-ERG1 antibody

Information sourced from Uniprot.org