| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPTBN1 |
| Gene ID: | 6711 |
| Uniprot ID: | SPTB2_HUMAN |
| Immunogen Region: | 2100-2200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 2100-2200 of human SPTBN1 (NP_003119.2). |
| Immunogen Sequence: | PPSPEPSTKVSEEAESQQQW DTSKGEQVSQNGLPAEQGSP RMAETVDTSEMVNGATEQRT SSKESSPIPSPTSDRKAKTA LPAQSAATLPARTQETPSAQ M |
| Tissue Specificity | Isoform 2 is present in brain, lung and kidney (at protein level). |
| Function | Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. |
| Protein Name | Spectrin Beta Chain - Non-Erythrocytic 1Beta-Ii SpectrinFodrin Beta ChainSpectrin - Non-Erythroid Beta Chain 1 |
| Database Links | Reactome: R-HSA-373753Reactome: R-HSA-375165Reactome: R-HSA-445095Reactome: R-HSA-5673001Reactome: R-HSA-6807878Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9703465 |
| Cellular Localisation | CytoplasmCytoskeletonMyofibrilSarcomereM LineCytosolCell MembraneColocalizes With Ank2 In A Distinct Intracellular Compartment Of Neonatal CardiomyocytesIsoform 2: Cell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Spectrin Beta Chain - Non-Erythrocytic 1 antibodyAnti-Beta-Ii Spectrin antibodyAnti-Fodrin Beta Chain antibodyAnti-Spectrin - Non-Erythroid Beta Chain 1 antibodyAnti-SPTBN1 antibodyAnti-SPTB2 antibody |
Information sourced from Uniprot.org